Main Therapy Choices
Pills – Swallowed & absorbed through the digestive tract into circulation. Requires liver metabolism. Best for peri-menopausal phase.
Creams – Water-based gels or emulsified creams penetrate the skin barrier for transdermal absorption. Some creams also provide localized vaginal benefits.
Injections – Delivered into fat tissue or muscle to prolong absorption time. Most direct way to boost circulating levels. Short dosing intervals.
Pellets - Tiny bioidentical hormone pellets implanted under the hip skin steadily release hormones up to 5 months. Most convenient long-term administration with steady hormone levels. Local anesthesia is used.
Vaginal Inserts – Vaginal rings, tablets, or suppositories provide direct relief of local tissue discomfort in the urogenital tract. Useful alone or paired with systemic options.
Sublingual – Rapid mucus membrane absorption from hormones held under the tongue. Direct entry into the bloodstream bypasses the liver.
Transdermal Patches – Worn on the skin to allow hormones from the patch reservoir to passively diffuse into circulation through the skin steadily 24/7. Requires weekly application.
BioTE Method - Subcutaneous pellet implantation combined with cytokine testing to address hormone receptors sensitivity. Claims improved precision.
With wide flexibility in options, most find a method matches their needs and preferences well. Starting with lower doses and titrating up allows the body to adjust before balancing at an optimal level.
See the comparison table below highlighting key differences:
Admin Method | Onset | Duration | Advantages | Disadvantages |
---|---|---|---|---|
Pills | Variable ~2 wks | Daily dosing | Convenience Low cost | Liver metabolism Daily need |
Creams | Variable ~2 wks | Daily applications | Transdermal Local/systemic | Multiple daily doses Messy |
Injections | Within days | Varies weeks to months | Direct peak absorption | Frequent doctor's appointments Discomfort |
Pellets | Gradual ~3 wks | Months (4-6 avg) | Steady levels Long duration | Initial insertion procedure Minor surgery |
Vaginal Inserts | Rapid relief | Several days | Localized relief Minimum systemic absorption | Need separate systemic option Limited relief options |
Patches | Steady ~1 wk | Weekly application | Passive absorption Avoid peaks/valleys | Skin reactions Site rotation |
Sublingual | Rapid direct | Hourly absorption | Convenience No injections | Frequent daily dosing |